Response to aspirin in healthy individuals

Abstract

SummaryVariable biological effect of aspirin is suggested to be related to pharmacological resistance. The incidence of this so-called “resistant” state varies with the study population and the assay used. We determined performance features of five assays used to assess aspirin effects in non-smoking healthy volunteers not taking any drug known to interfere with platelet function. Blood and urine samples were obtained immediately before and after 8–10 days of aspirin 80 mg intake. Forty-five participants 19–59 years old were enrolled. The sensitivity (SE), specificity (SP), and optimal cut-off (CO) value to detect the effect of aspirin were: light transmission aggregometry (LTA) with 1.6 mM arachidonic acid (AA) – SE 100%,SP 95.9%,CO 20%;LTA with adenosine diphosphate (ADP) 10 µM – SE 84.4%, SP 77.8%, CO 70%; Ver-