Abstract
Aedes aegypti is the main transmitter of several arboviruses, such as dengue, the world's most widespread arbovirus. The main method of controlling arbovirus transmission is through vector control, using insecticides. But its continuous, cases of resistance occur. Thus, research is seeking new botanical insecticide alternatives, because have multiple active compounds can be applied on the vector, contributing to the control of arbovirus transmission. The aim of this study is to identify plants cultivated in the Western Amazon, which have larvicidal activity against A. aegypti. Ethanolic extracts from ten plants were obtained to verify the larvicidal biopotential against third instar larvae of A. aegypti. The promising ethanolic extracts was Fridericia chica, which was submitted to liquid-liquid partition for larvicidal activity evaluation and phytochemical analysis. Among the partitions analyzed, the aqueous partition of F. chica showed larvicidal biopotential against A. aegypti, being the first report in the literature of its larvicidal activity. In the phytochemical prospection of the aqueous partition of F. chica, we observed the presence of catechins, condensed tannins and the flavone group, flavonols and xanthones. These groups of metabolites have been reported in the literature as larvicidal agents.
Publisher
Fiocruz - Instituto de Tecnologia em Farmacos