Author:
Cruz Filipe Jonas Federico da,Souza Daniel Ferreira Almeida de,Anjos Samila Fernandes dos Santos,Barbosa Ana Paula Fernandes,Marques Juliana Pedrosa de Holanda,Barros Svetlana Maria Wanderley de,Santana Antonio Euzebio Goulart,Moreira Magna Suzana Alexandre,Jucá Mario Jorge
Abstract
Search for new therapeutic agents and alternative strategies for chemoprevention of colorectal cancer is needed to reduce morbidity and mortality resulting from this disease. This study aimed to compare the effect of aqueous extract of Sida cordifolia L. and 5- fluorouracil (5-FU) on colon carcinogenesis induced by 1,2- dimethylhydrazine (1,2-DMH). The extract reduced the frequency of aberrant crypts to regarding the positive control, but there was no significant difference among the positive control animals, those who received the extract and those receiving standard anticancer drug. Thus, the aqueous extract of Sida cordifolia L. 800 mg/kg showed no statistical impact on carcinogenesis in animal models, but showed a significant anti-inflammatory effect on the colon mucosa.
Publisher
Fiocruz - Instituto de Tecnologia em Farmacos
Subject
General Engineering,Ocean Engineering
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