Anti-proliferative and anti-inflammatory activity of triterpene extracts from plant species belonging to Lamiaceae family
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Published:2023-11-30
Issue:6
Volume:22
Page:864-878
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ISSN:0717-7917
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Container-title:Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
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language:
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Short-container-title:BLACPMA
Author:
Jordamovc NadirORCID,
,
Pehlivanovic BelmaORCID,
Niksic HarisORCID,
Gusic IrmaORCID,
Koric EminaORCID,
Dedic MirzaORCID,
Tuna-Repovac BelmaORCID,
Becic FahirORCID,
Duric KemalORCID,
,
,
,
,
,
,
,
Abstract
Triterpenes are very important secondary metabolites with wide structural diversity and significant role in pharmacy and medicine.In the present research, a comparative study of pharamacological activities of the triterpene fractions obtained from several plant species belonging to Lamiaceae family, was carried out. In-vitro anti-proliferative activity was performed using a standardproliferation assay based on tetrazolium salts. In vitro anti-inflammatory activity of triterpene fractions was determined by an assay of inhibition of albumin denaturation. In general, the triterpene fractions obtained from plant species belonging to Lamiaceae family showed a strong anti-proliferative activity and anti-inflammatory activity.The triterpene fraction of Rosmarini folium showed the strongest anti-proliferative activity (GI50range from 4 to 37 μg/ml) and the strongest anti-inflammatory activity in the range from 57.27% to 80.69%. This comparative study provides scientific evidence to support the traditional use of Lamiacae plant species for medical purposes as anti-inflammatory and anti-proliferative medicines.
Subject
Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology