Author:
Ma Zhiyuan,Ni Feng,Woo Grace H C,Lo Sie-Mun,Roveto Philip M,Schaus Scott E,Snyder John K
Abstract
Intramolecular inverse electron demand cycloadditions of isatin-derived 1,2,4-triazines with acetylenic dienophiles tethered by amidations or transesterifications proceed in excellent yields to produce lactam- or lactone-fused α-carbolines. Beginning with various isatins and alkynyl dienophiles, a pilot-scale library of eighty-eight α-carbolines was prepared by using this robust methodology for biological evaluation.
Cited by
23 articles.
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