Author:
Kumar Amit,Vachhani Dipak D,Modha Sachin G,Sharma Sunil K,Parmar Virinder S,Van der Eycken Erik V
Abstract
An Ugi four-component reaction of propargylamine with 3-formylindole and various acids and isonitriles produces adducts which are subjected to a cationic gold-catalyzed diastereoselective domino cyclization to furnish diversely substituted spiroindolines. All the reactions run via an exo-dig attack in the hydroarylation step followed by an intramolecular diastereoselective trapping of the imminium ion. The whole sequence is atom economic and the application of a multicomponent reaction assures diversity.
Cited by
44 articles.
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