Abstract
A highly divergent synthesis of regioisomeric thiohydantoins and pseudothiohydantoins spiro-fused to a pharmacologically valuable pyrrole-2-one fragment involving the reaction of [e]-fused 1H-pyrrole-2,3-diones with thioureas was developed. The obtained spiro pseudothiohydantoin derivatives were found to undergo a pseudothiohydantoin–thiohydantoin rearrangement. The reactions were shown to proceed under catalyst-free conditions in good yields, and the products were isolated without applying preparative chromatography methods.
Cited by
8 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Switchable Synthesis of Benzothiazoles, Benzothiazines and Benzothiazepines through the Reaction of Hetareno[e]pyrrole‐2,3‐Diones with o‐Aminothiophenol;ChemistrySelect;2024-03-13
2. Synthesis of heterocycles by use of thioureas as chiral auxiliaries and as reactants;Phosphorus, Sulfur, and Silicon and the Related Elements;2022-10-18
3. Synthesis of Hydantoins Spiro-Annulated to the Pyrrole Ring, by the Reaction of Pyrrolo[1,2-c][4,1]benzoxazepinetriones with Urea and Thiourea;Russian Journal of Organic Chemistry;2022-02
4. Reaction of Hetareno[
e
]pyrrole‐2,3‐diones with Thiols: An Approach to Two Distinct 5‐Thio‐Substituted Pyrrole‐2‐one Derivatives;ChemistrySelect;2021-12
5. Reaction of Pyrrolobenzoxazinetriones with N,N′-Disubstituted Ureas. Synthesis of Substituted Spiro[imidazole-2,2′-pyrroles];Russian Journal of Organic Chemistry;2021-09