Enantioselective PCCP Brønsted acid-catalyzed aminalization of aldehydes

Author:

Kamlar MartinORCID,Reiberger RobertORCID,Nigríni Martin,Císařová IvanaORCID,Veselý JanORCID

Abstract

Here we present an enantioselective aminalization of aldehydes catalyzed by Brønsted acids based on pentacarboxycyclopentadienes (PCCPs). The cyclization reaction using readily available anthranilamides as building blocks provides access to valuable 2,3-dihydroquinazolinones containing one stereogenic carbon center with good enantioselectivity (ee up to 80%) and excellent yields (up to 97%).

Funder

Grantová Agentura České Republiky

Publisher

Beilstein Institut

Subject

Organic Chemistry

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Synthetic approaches toward 2,3-dihydroquinazolinones (microreview);Chemistry of Heterocyclic Compounds;2023-08

2. PCCP‐Catalyzed Synthesis of Tetrasubstituted Allenes Bearing Heteroaromatic Sulfenyl Group**;European Journal of Organic Chemistry;2023-07-20

3. Seven-membered rings;Progress in Heterocyclic Chemistry;2023

4. New advances in asymmetric organocatalysis;Beilstein Journal of Organic Chemistry;2022-02-28

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