Author:
Ivanov A V,Shcherbakova V S,Ushakov I A,Sobenina L N,Petrova O V,Mikhaleva A I,Trofimov B A
Abstract
1-Vinylpyrrole-2-carbaldehydes react with acetylene at atmospheric pressure in a NaOH/EtOH/DMSO system at 7–10 °C to afford 2-(1-hydroxypropyn-2-yl)-1-vinylpyrroles in 53–94% yield. Thus, the first base-mediated direct ethynylation of pyrrolecarbaldehydes with free acetylene under modified conditions of the Favorsky reaction has been implemented to pave an expedient route to important biomolecules containing a pyrrole ring.
Cited by
6 articles.
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