Author:
Smadhi Meriem,de Bentzmann Sophie,Imberty Anne,Gingras Marc,Abderrahim Raoudha,Goekjian Peter G
Abstract
Readily accessible, low-valency glycoclusters based on a triazine core bearing D-galactose and L-fucose epitopes are able to inhibit biofilm formation by Pseudomonas aeruginosa. These multivalent ligands are simple to synthesize, are highly soluble, and can be either homofunctional or heterofunctional. The galactose-decorated cluster shows good affinity for Pseudomonas aeruginosa lectin lecA. They are convenient biological probes for investigating the roles of lecA and lecB in biofilm formation.
Cited by
12 articles.
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