Low Hematocrit and Serum Albumin Concentrations Underlie the Overestimation of Tacrolimus Concentrations by Microparticle Enzyme Immunoassay versus Liquid Chromatography–Tandem Mass Spectrometry
Author:
Affiliation:
1. Immunosuppressive Drug Monitoring, Institute of Liver Studies, King’s College Hospital, London, UK
2. Institute of Liver Studies, Guy’s King’s and St. Thomas’ School of Medicine, King’s College London, London, UK
Abstract
Publisher
Oxford University Press (OUP)
Subject
Biochemistry (medical),Clinical Biochemistry
Link
http://academic.oup.com/clinchem/article-pdf/51/3/586/32684065/clinchem0586.pdf
Reference25 articles.
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2. Levy G, Villamil F, Samuel D, Sanjuan F, Grazi GL, Wu Y, et al. Results of LIS2T, a multicentre, randomized study comparing cyclosporine microemulsion with C2 monitoring and tacrolimus with C0 monitoring in de novo liver transplantation. Transplantation2004;77:1632-1638.
3. Kaufman DB, Shapiro R, Lucey MR, Cherikh WS, Bustami RT, Dyke DB. Immunosuppression: practice and trends. Am J Transplant2004;4:38-53.
4. Tredger JM, Gilkes CD, Gonde CE. Therapeutic monitoring of tacrolimus (FK506) with the first and second-generation microparticle enzyme immunoassays: performance and results in four patient populations. Ther Drug Monit1998;20:266-275.
5. Schambeck CM, Bedel A, Keller F. Limit of quantification (functional sensitivity) of the new IMx tacrolimus II microparticle enzyme immunoassay. Clin Chem1998;44:2217.
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