Dairy Intake and Body Composition and Cardiometabolic Traits among Adults: Mendelian Randomization Analysis of 182041 Individuals from 18 Studies-Reference-Cited by-同舟云学术

Dairy Intake and Body Composition and Cardiometabolic Traits among Adults: Mendelian Randomization Analysis of 182041 Individuals from 18 Studies

Published:2019-06-01 Issue:6 Volume:65 Page:751-760
ISSN:0009-9147
Container-title:Clinical Chemistry
language:en
Short-container-title:

Author:

, ,Huang Tao¹²³,Sun Dianjianyi⁴⁵,Heianza Yoriko⁴⁵,Bergholdt Helle K M⁶,Gao Meng¹,Fang Zhe¹,Ding Ming⁷,Frazier-Wood Alexis C⁸,North Kari E⁹,Marouli Eirini¹⁰¹¹,Graff Mariaelisa⁹,Smith Caren E¹²,Varbo Anette¹³¹⁴,Lemaitre Rozenn N¹⁵¹⁶,Corella Dolores¹⁷¹⁸,Wang Carol A¹⁹,Tjønneland Anne²⁰,Overvad Kim²¹²²,Sørensen Thorkild I A²³²⁴,Feitosa Mary F²⁵,Wojczynski Mary K²⁵,Kähönen Mika²⁶,Mikkilä Vera²⁷,Bartz Traci M¹⁶²⁸,Psaty Bruce M²⁹³⁰,Siscovick David S³¹,Danning Rebecca D³²,Dedoussis George³³,Pedersen Oluf²³³⁴,Hansen Torben²³,Havulinna Aki S³⁵,Männistö Satu³⁵,Rotter Jerome I³⁶,Sares-Jäske Laura³⁷,Allison Mathew A³⁸,Rich Stephen S³⁹,Sorlí Jose V¹⁷¹⁸,Coltell Oscar¹⁸⁴⁰,Pennell Craig E⁴¹⁴²,Eastwood Peter⁴³,Ridker Paul M³²⁴⁴,Viikari Jorma⁴⁵⁴⁶,Raitakari Olli⁴⁷⁴⁸,Lehtimäki Terho⁴⁹⁵⁰,Helminen Mika⁵¹⁵²,Wang Yujie⁹,Deloukas Panagiotis¹⁰¹¹⁵³,Knekt Paul³⁷,Kanerva Noora³⁵⁵⁴,Kilpeläinen Tuomas O²³,Province Michael A²⁵,Mozaffarian Dariush⁵⁵,Chasman Daniel I³²⁵⁶⁵⁷,Nordestgaard Børge G¹³¹⁴⁵⁸,Ellervik Christina¹⁴⁵⁹⁶⁰,Qi Lu⁴⁵⁷

Affiliation:

1. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China

2. Department of Global Health, School of Public Health, Peking University, Beijing, China

3. Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China

4. Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA

5. Tulane University Obesity Research Center, Tulane University, New Orleans, LA

6. Department of Clinical Biochemistry, Naestved Hospital, Naestved, Denmark

7. Department of Nutrition, Harvard School of Public Health, Boston, MA

8. USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX

9. Department of Epidemiology, University of North Carolina, Chapel Hill, NC

10. William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

11. Centre for Genomic Health, Life Sciences, Queen Mary University of London, London, UK

12. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA

13. Department of Clinical Biochemistry and the Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark

14. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

15. Department of Medicine, University of Washington, Seattle, WA

16. Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA

17. Department of Preventive Medicine and Public Health, University of Valencia, Valencia, Spain

18. CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain

19. School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, New South Wales, Australia

20. Danish Cancer Society Research Center, Copenhagen, Denmark

21. Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark

22. Aalborg University Hospital, Aalborg, Denmark

23. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

24. Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

25. Department of Genetics, Washington University School of Medicine, Saint Louis, MO

26. Department of Clinical Physiology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland

27. Division of Nutrition, Department of Food and Environmental Sciences, Helsinki, Finland

28. Department of Biostatistics, University of Washington, Seattle, WA

29. Kaiser Permanente Washington Health Research Institute, Seattle, WA

30. Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA

31. New York Academy of Medicine, New York, NY

32. Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

33. Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece

34. Faculty of Health Sciences, University of Aarhus, Aarhus, Denmark

35. Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland

36. Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA

37. National Institute for Health and Welfare, Helsinki, Finland

38. Division of Preventive Medicine, Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA

39. Center for Public Health Genomics and Department of Public Health Sciences, University of Virginia, Charlottesville, VA

40. Department of Computer Languages and Systems, University Jaume I, Castellon, Spain

41. School of Human Sciences, The University of Western Australia, Western Australia, Australia

42. Western Australian Sleep Disorders Research Institute, Department of Pulmonary Physiological and Sleep Medicine, Sir Charles Gairdner Hospital, Western Australia, Australia

43. School of Anatomy, Physiology and Human Biology, The University of Western Australia, Western Australia, Australia

44. Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

45. Division of Medicine, Turku University Hospital, Turku, Finland

46. Department of Medicine, University of Turku, Turku, Finland

47. Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland

48. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland

49. Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland

50. Department of Clinical Chemistry, Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, University of Tampere, Tampere, Finland

51. Research, Development and Innovation Centre, Tampere University Hospital, Tampere, Finland

52. Faculty of Social Sciences, Health Sciences, University of Tampere, Tampere, Finland

53. Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia

54. Department of Public Health, University of Helsinki, Helsinki, Finland

55. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA

56. Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

57. Broad Institute of MIT and Harvard, Cambridge, MA

58. The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, Denmark

59. Department of Production, Research, and Innovation, Regionshuset, Soroe, Denmark

60. Department of Laboratory Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA

Abstract

Abstract BACKGROUND Associations between dairy intake and body composition and cardiometabolic traits have been inconsistently observed in epidemiological studies, and the causal relationship remains ill-defined. METHODS We performed Mendelian randomization analysis using an established genetic variant located upstream of the lactase gene (LCT-13910 C/T, rs4988235) associated with dairy intake as an instrumental variable (IV). The causal effects of dairy intake on body composition and cardiometabolic traits (lipids, glycemic traits, and inflammatory factors) were quantified by IV estimators among 182041 participants from 18 studies. RESULTS Each 1 serving/day higher dairy intake was associated with higher lean mass [β (SE) = 0.117 kg (0.035); P = 0.001], higher hemoglobin A1c [0.009% (0.002); P < 0.001], lower LDL [−0.014 mmol/L (0.006); P = 0.013], total cholesterol (TC) [−0.012 mmol/L (0.005); P = 0.023], and non-HDL [−0.012 mmol/L (0.005); P = 0.028]. The LCT-13910 C/T CT + TT genotype was associated with 0.214 more dairy servings/day (SE = 0.047; P < 0.001), 0.284 cm higher waist circumference (SE = 0.118; P = 0.017), 0.112 kg higher lean mass (SE = 0.027; P = 3.8 × 10−5), 0.032 mmol/L lower LDL (SE = 0.009; P = 0.001), and 0.032 mmol/L lower TC (SE = 0.010; P = 0.001). Genetically higher dairy intake was associated with increased lean mass [0.523 kg per serving/day (0.170); P = 0.002] after correction for multiple testing (0.05/18). However, we find that genetically higher dairy intake was not associated with lipids and glycemic traits. CONCLUSIONS The present study provides evidence to support a potential causal effect of higher dairy intake on increased lean mass among adults. Our findings suggest that the observational associations of dairy intake with lipids and glycemic traits may be the result of confounding.

Funder

NHLBI

NIDDK

NIH

Publisher

Oxford University Press (OUP)

Subject

Biochemistry (medical),Clinical Biochemistry

Link

http://academic.oup.com/clinchem/article-pdf/65/6/751/32638569/clinchem0751.pdf

Reference35 articles.

1. Lactase persistence and body mass index: the contribution of Mendelian randomization;Hartwig;Clin Chem,2018