Diagnostic Pitfall in PCR-Based α-Thalassemia Genotyping Resulting from a (G→C) Polymorphism at Nucleotide 71 3′ to the α2-Globin Gene Termination Codon-Reference-Cited by-同舟云学术

Diagnostic Pitfall in PCR-Based α-Thalassemia Genotyping Resulting from a (G→C) Polymorphism at Nucleotide 71 3′ to the α2-Globin Gene Termination Codon

Published:2006-03-01 Issue:3 Volume:52 Page:536-537
ISSN:0009-9147
Container-title:Clinical Chemistry
language:en
Short-container-title:

Author:

Chan Amy Yuk-Yin¹,Luo Hong-Yuan²,Wang Wen³,Chui David HK²,Ma Edmond Shiu-Kwan⁴,Chan Li-Chong¹,Chong Samuel S³

Affiliation:

1. Division of Hematology, Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, ROC

2. Departments of Medicine, and Pathology, Boston University, School of Medicine, Boston, MA

3. Departments of Pediatrics, and Children’s Medical Institute, National University of Singapore, and Hospital, Singapore

4. Department of Pathology, Hong Kong Sanatorium, and Hospital, Hong Kong, ROC

Publisher

Oxford University Press (OUP)

Subject

Biochemistry, medical,Clinical Biochemistry

Link

http://academic.oup.com/clinchem/article-pdf/52/3/536/32686807/clinchem0536.pdf

Reference3 articles.

1. Tan AS, Quah TC, Low PS, Chong SS. A rapid and reliable 7-deletion multiplex polymerase chain reaction assay for α-thalassemia. Blood2001;98:150-151.

2. Wang W, Ma ESK, Chan AYY, Chui DHK, Chong SS. Multiplex minisequencing screen for seven Southeast Asian nondeletional α-thalassemia mutations. Clin Chem2003;49:800-803.

3. Dode C, Rochette J, Krishnamoorthy R. Locus assignment of human α globin mutations by selective amplification and direct sequencing. Br J Haematol1990;76:275-281.

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