Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies-Reference-Cited by-同舟云学术

Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies

Published:2018-01-01 Issue:1 Volume:64 Page:183-191
ISSN:0009-9147
Container-title:Clinical Chemistry
language:en
Short-container-title:

Author:

Huang Tao¹²³⁴,Ding Ming⁴,Bergholdt Helle K M⁵⁶⁷,Wang Tiange³,Heianza Yoriko³,Sun Dianjianyi³,Frazier-Wood Alexis C⁸,Aslibekyan Stella⁹,North Kari E¹⁰,Voortman Trudy¹¹,Graff Mariaelisa¹⁰,Smith Caren E¹²,Lai Chao-Qiang¹²,Varbo Anette⁶¹³,Lemaitre Rozenn N¹⁴,de Jonge M Ester A L¹¹,Fumeron Frédéric¹⁵¹⁶¹⁷,Corella Dolores¹⁸¹⁹,Wang Carol A²⁰,Tjønneland Anne²¹,Overvad Kim²²²³,Sørensen Thorkild I A²⁴²⁵,Feitosa Mary F²⁶,Wojczynski Mary K²⁶,Kähönen Mika²⁷²⁸,Renström Frida²⁹³⁰,Psaty Bruce M³¹³²,Siscovick David S³³,Barroso Inês³⁴³⁵³⁶,Johansson Ingegerd³⁷,Hernandez Dena³⁸,Ferrucci Luigi³⁹,Bandinelli Stefania⁴⁰,Linneberg Allan⁴¹⁴²,Zillikens M Carola⁴³,Sandholt Camilla Helene²⁴,Pedersen Oluf²⁴⁴⁴,Hansen Torben²⁴,Schulz Christina-Alexandra⁴⁵,Sonestedt Emily⁴⁵,Orho-Melander Marju⁴⁵,Chen Tzu-An⁸,Rotter Jerome I⁴⁶,Allison Mathew A⁴⁷,Rich Stephen S⁴⁸,Sorlí Jose V¹⁸¹⁹,Coltell Oscar¹⁹⁴⁹,Pennell Craig E²⁰,Eastwood Peter⁵⁰,Hofman Albert¹¹,Uitterlinden Andre G⁴³,van Rooij Frank J A¹¹,Chu Audrey Y⁵¹,Rose Lynda M⁵¹,Ridker Paul M⁵¹⁵²,Viikari Jorma⁵³⁵⁴,Raitakari Olli⁵⁵⁵⁶,Lehtimäki Terho⁵⁷⁵⁸,Mikkilä Vera⁵⁶⁵⁹,Willett Walter C⁴⁶⁰⁶¹,Wang Yujie¹⁰,Tucker Katherine L⁶²,Ordovas Jose M¹²⁶³⁶⁴,Kilpeläinen Tuomas O²⁴,Province Michael A²⁶,Franks Paul W⁴²⁹⁶⁵,Arnett Donna K⁶⁶,Tanaka Toshiko³⁹,Toft Ulla⁴¹,Ericson Ulrika⁴⁵,Franco Oscar H¹¹,Mozaffarian Dariush⁶⁷,Hu Frank B⁴⁶⁰⁶¹,Chasman Daniel I⁵¹⁶⁸⁶⁹,Nordestgaard Børge G⁶¹³⁷⁰,Ellervik Christina⁶⁷¹⁷²,Qi Lu³⁴⁷³,

Affiliation:

1. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China

2. Epidemiology Domain, Saw Swee Hock School of Public Health, National University of Singapore, Singapore

3. Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA

4. Department of Nutrition, Harvard School of Public Health, Boston, MA

5. Department of Clinical Biochemistry, Naestved Hospital, Naestved, Denmark

6. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

7. Department of Clinical Pharmacology, Copenhagen University Hospital Bispebjerg Frederiksberg, Copenhagen, Denmark

8. USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX

9. Department of Epidemiology, School of Public Health, University of Alabama, Birmingham, AL

10. Department of Epidemiology, University of North Carolina, Chapel Hill, NC

11. Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands

12. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA

13. Department of Clinical Biochemistry and the Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark

14. Department of Medicine, University of Washington, Seattle, WA

15. INSERM, UMR S 1138, Centre de Recherche des Cordeliers, Paris, France

16. University Paris Diderot, Sorbonne Paris Cité, UMR S 1138, Centre de Recherche des Cordeliers, Paris, France

17. Sorbonne Universités, UPMC University Paris 06, UMR S 1138, Centre de Recherche des Cordeliers, Paris, France

18. Department of Preventive Medicine and Public Health, University of Valencia, Valencia, Spain

19. CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain

20. School of Women's and Infants' Health, The University of Western Australia, Crawley, WA, Australia

21. Danish Cancer Society Research Center, Copenhagen, Denmark

22. Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark

23. Aalborg University Hospital, Aalborg, Denmark

24. Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

25. Department of Public Health Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

26. Department of Genetics, Washington University School of Medicine, St. Louis, MO

27. Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland

28. Department of Clinical Physiology Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland

29. Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden

30. Department of Biobank Research, Umeå University, Umeå, Sweden

31. Kaiser Permanent Washington Health Research Institute, Seattle, WA

32. Cardiovascular Health Research Unit Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA

33. New York Academy of Medicine, New York, NY

34. NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK

35. University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK

36. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

37. Department of Odontology, Umeå University, Umeå, Sweden

38. Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD

39. Translational Gerontology Branch National Institute on Aging, Baltimore, MD

40. Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy

41. Research Centre for Prevention and Health, the Capital Region of Denmark, Copenhagen, Denmark

42. Department of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark

43. Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, the Netherlands

44. Faculty of Health Sciences, University of Aarhus, Aarhus, Denmark

45. Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden

46. Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA

47. Division of Preventive Medicine, Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA

48. Center for Public Health Genomics and Department of Public Health Sciences, University of Virginia, Charlottesville, VA

49. Department of Computer Languages and Systems, University Jaume I, Castellon, Spain

50. School of Anatomy, Physiology and Human Biology, The University of Western Australia, Western Australia, Australia

51. Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

52. Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

53. Division of Medicine, Turku University Hospital, Turku, Finland

54. Department of Medicine, University of Turku, Turku, Finland

55. Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland

56. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland

57. Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland

58. Department of Clinical Chemistry Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland

59. Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland

60. Department of Epidemiology, Harvard School of Public Health, Boston, MA

61. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

62. Biomedical and Nutritional Sciences, Center for Population Health, University of Massachusetts Lowell, Lowell, MA

63. Department of Epidemiology and Population Genetics, Centro Nacional Investigación Cardiovasculares (CNIC), Madrid, Spain

64. Instituto Madrileño de Estudios Avanzados en Alimentación, Madrid, Spain

65. Department of Public Health and Clinical Medicine, Section for Medicine, Umeå University, Umeå, Sweden

66. Dean's Office, University of Kentucky, Lexington, KY

67. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA

68. Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

69. Broad Institute of MIT and Harvard, Cambridge, MA

70. The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, Denmark

71. Department of Production Research and Innovation, Regionshuset, Soroe, Denmark

72. Department of Laboratory Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA

73. Tulane University Obesity Research Center, Tulane University, New Orleans, LA

Abstract

Abstract BACKGROUND Associations between dairy intake and body mass index (BMI) have been inconsistently observed in epidemiological studies, and the causal relationship remains ill defined. METHODS We performed Mendelian randomization (MR) analysis using an established dairy intake-associated genetic polymorphism located upstream of the lactase gene (LCT-13910 C/T, rs4988235) as an instrumental variable (IV). Linear regression models were fitted to analyze associations between (a) dairy intake and BMI, (b) rs4988235 and dairy intake, and (c) rs4988235 and BMI in each study. The causal effect of dairy intake on BMI was quantified by IV estimators among 184802 participants from 25 studies. RESULTS Higher dairy intake was associated with higher BMI (β = 0.03 kg/m2 per serving/day; 95% CI, 0.00–0.06; P = 0.04), whereas the LCT genotype with 1 or 2 T allele was significantly associated with 0.20 (95% CI, 0.14–0.25) serving/day higher dairy intake (P = 3.15 × 10−12) and 0.12 (95% CI, 0.06–0.17) kg/m2 higher BMI (P = 2.11 × 10−5). MR analysis showed that the genetically determined higher dairy intake was significantly associated with higher BMI (β = 0.60 kg/m2 per serving/day; 95% CI, 0.27–0.92; P = 3.0 × 10−4). CONCLUSIONS The present study provides strong evidence to support a causal effect of higher dairy intake on increased BMI among adults.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry (medical),Clinical Biochemistry

Link

http://academic.oup.com/clinchem/article-pdf/64/1/183/32642112/clinchem0183.pdf

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