1. From the Departments of Oncology, Biostatistics, Pathology, and Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN; Department of Medicine, Division of Hematology/Oncology; University of Michigan School of Medicine, Ann Arbor, MI; Department of Medicine, Division of Clinical Pharmacology, Indiana University, Bloomington, IN; and Department of Medicine, Division of Hematology and Oncology; Mayo Clinic Jacksonville, Jacksonville, FL.