COMBI-d: A randomized, double-blinded, Phase III study comparing the combination of dabrafenib and trametinib to dabrafenib and trametinib placebo as first-line therapy in patients (pts) with unresectable or metastatic BRAFV600E/K mutation-positive cutaneous melanoma

Author:

Long Georgina V.1,Stroyakovsky Daniil L.2,Gogas Helen3,Levchenko Eugeny4,de Braud Filippo5,Larkin James M. G.6,Garbe Claus7,Jouary Thomas8,Hauschild Axel9,Grob Jean Jacques10,Chiarion-Sileni Vanna11,Lebbe Celeste12,Mandalà Mario13,Millward Michael14,DeMarini Douglas James15,Irani Jhangir G16,Le Ngocdiep17,Casey Michelle16,Patel Kiran16,Flaherty Keith18

Affiliation:

1. Melanoma Institute Australia, Sydney, Australia

2. Moscow City Oncology Hospital, Chemotherapy Department, Moscow, Russia

3. University of Athens, Athens, Greece

4. Petrov Research Institute of Oncology, Saint Petersburg, Russia

5. Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy

6. Royal Marsden Hospital, London, United Kingdom

7. Department of Dermatology, University Hospital Tuebingen, Tuebingen, Germany

8. Saint André Hospital CHU de Bordeaux, Dermatology, Bordeaux, France

9. University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

10. Service de Dermatologie, Centre Hospitalo-Universitaire Sainte-Marguerite, Marseille, France

11. IOV-IRCCS, Melanoma Oncology Unit, Padova, Italy

12. APHP Hôpital Saint Louis, University Paris Diderot, Paris, France

13. Papa Giovanni XIII Hospital, BErgamo, Italy

14. Sir Charles Gairdner Hospital, Perth, Australia

15. GlaxoSmithKline, Research Triangle Park, NC

16. GlaxoSmithKline, Collegeville, PA

17. Novartis Pharmaceuticals Corporation, East Hanover, NJ

18. Massachusetts General Hospital Cancer Center,Harvard Medical School, Boston, MA

Publisher

American Society of Clinical Oncology (ASCO)

Subject

Cancer Research,Oncology

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