Imatinib in Melanoma: A Selective Treatment Option Based on KIT Mutation Status?
Author:
Affiliation:
1. Department of Dermatology, Julius-Maximilians-University, Würzburg, Germany
2. Skin Cancer Unit, German Cancer Research Center Heidelberg and Department of Dermatology, Mannheim University Medical Center, Mannheim, Germany
Publisher
American Society of Clinical Oncology (ASCO)
Subject
Cancer Research,Oncology
Link
http://ascopubs.org/doi/pdfdirect/10.1200/JCO.2006.08.9664
Reference5 articles.
1. Somatic Activation of KIT in Distinct Subtypes of Melanoma
2. Distinct Sets of Genetic Alterations in Melanoma
3. Frost MJ, Ferrao PT, Hughes TP, et al: Juxtamembrane mutant V560GKit is more sensitive to imatinib (STI571) compared with wild-type c-kit whereas the kinase domain mutant D816VKit is resistant. Mol Cancer Ther 1:1115,2002-1124,
4. Lack of clinical efficacy of imatinib in metastatic melanoma
5. Multicenter Phase II trial of high-dose imatinib mesylate in metastatic melanoma
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