Treatment of Multiple Myeloma: ASCO and CCO Joint Clinical Practice Guideline

Author:

Mikhael Joseph12,Ismaila Nofisat3,Cheung Matthew C.4,Costello Caitlin5,Dhodapkar Madhav V.6,Kumar Shaji7,Lacy Martha7,Lipe Brea8,Little Richard F.9,Nikonova Anna10,Omel James11,Peswani Namrata12,Prica Anca13,Raje Noopur14,Seth Rahul15,Vesole David H.1617,Walker Irwin18,Whitley Alexander19,Wildes Tanya M.20,Wong Sandy W.21,Martin Tom21

Affiliation:

1. City of Hope Cancer Center, Phoenix, AZ

2. International Myeloma Foundation, North Hollywood, CA

3. American Society of Clinical Oncology, Alexandria VA

4. Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

5. UC San Diego Moores Cancer Center, La Jolla, CA

6. Emory University, Atlanta, GA

7. Mayo Clinic, Rochester MN

8. University of Rochester Medical Center, Rochester, NY

9. National Cancer Institute, Bethesda, MD

10. Juravinski Cancer Center, Hamilton, Ontario, Canada

11. Education and Advocacy, Grand Island, NE

12. Advocate Medical Group, Chicago, IL

13. Princess Margaret Cancer Centre, Toronto, Ontario, Canada

14. Massachusetts General Hospital, Boston, MA

15. Upstate Medical University, Syracuse, NY

16. Hackensack University Medical Center, Hackensack, NJ

17. Georgetown University, Washington, DC

18. McMaster University, Hamilton, Ontario, Canada

19. Central Alabama Radiation Oncology, Montgomery, AL

20. Washington University Medical School, St Louis, MO

21. University of California San Francisco, San Francisco, CA

Abstract

PURPOSE To provide evidence-based recommendations on the treatment of multiple myeloma to practicing physicians and others. METHODS ASCO and Cancer Care Ontario convened an Expert Panel of medical oncology, surgery, radiation oncology, and advocacy experts to conduct a literature search, which included systematic reviews, meta-analyses, randomized controlled trials, and some phase II studies published from 2005 through 2018. Outcomes of interest included survival, progression-free survival, response rate, and quality of life. Expert Panel members used available evidence and informal consensus to develop evidence-based guideline recommendations. RESULTS The literature search identified 124 relevant studies to inform the evidence base for this guideline. RECOMMENDATIONS Evidence-based recommendations were developed for patients with multiple myeloma who are transplantation eligible and those who are ineligible and for patients with relapsed or refractory disease.

Publisher

American Society of Clinical Oncology (ASCO)

Subject

Cancer Research,Oncology

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