Pembrolizumab in Patients With Tumors With High Tumor Mutational Burden: Results From the Targeted Agent and Profiling Utilization Registry Study

Author:

Duvivier Herbert L.1,Rothe Michael2,Mangat Pam K.2ORCID,Garrett-Mayer Elizabeth2ORCID,Ahn Eugene R.3,Al Baghdadi Tareq4,Alva Ajjai S.5,Dublis Stephanie A.6,Cannon Timothy L.7ORCID,Calfa Carmen J.8ORCID,Li Rui9,Behl Deepti10ORCID,Chiu Vi K.11,Gold Philip J.12,Marr Alissa S.13ORCID,Mileham Kathryn F.14ORCID,Powell Steven Francis15ORCID,Rodon Jordi16ORCID,Thota Ramya17ORCID,Grantham Gina N.2ORCID,Gregory Abigail2ORCID,Hinshaw Dominique C.2ORCID,Halabi Susan18ORCID,Schilsky Richard L.2ORCID

Affiliation:

1. Cancer Treatment Centers of America—Atlanta, Part of City of Hope, Newnan, GA

2. American Society of Clinical Oncology, Alexandria, VA

3. Cancer Treatment Centers of America—Chicago, Part of City of Hope, Zion, IL

4. Michigan Cancer Research Consortium, IHA Hematology Oncology, Ypsilanti, MI

5. University of Michigan Rogel Comprehensive Cancer Center, Ann Arbor, MI

6. University of Michigan Health-West, Wyoming, MI

7. Inova Schar Cancer Institute, Fairfax, VA

8. Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL

9. Providence Cancer Institute, Providence Portland Medical Center, Portland, OR

10. Sutter Sacramento Medical Center, Sacramento, CA

11. The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate, Los Angeles, CA

12. Swedish Cancer Institute, Seattle, WA

13. University of Nebraska Medical Center, Omaha, NE

14. Levine Cancer Institute, Atrium Health, Charlotte, NC

15. Sanford Health, Sioux Falls, SD

16. Department of Investigational Cancer Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX

17. Intermountain Healthcare, Murray, UT

18. Duke University Medical Center, Durham, NC

Abstract

#TAPUR results of pembrolizumab in various tumors with HTMB extend KEYNOTE-158 data that led to FDA approval in tumors with HTMB

Publisher

American Society of Clinical Oncology (ASCO)

Subject

Cancer Research,Oncology

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