Prophylactic Radiation Therapy Versus Standard of Care for Patients With High-Risk Asymptomatic Bone Metastases: A Multicenter, Randomized Phase II Clinical Trial-Reference-Cited by-同舟云学术

Prophylactic Radiation Therapy Versus Standard of Care for Patients With High-Risk Asymptomatic Bone Metastases: A Multicenter, Randomized Phase II Clinical Trial

Published:2024-01-01 Issue:1 Volume:42 Page:38-46
ISSN:0732-183X
Container-title:Journal of Clinical Oncology
language:en
Short-container-title:JCO

Author:

Gillespie Erin F.¹²^ORCID,Yang Joanna C.¹³,Mathis Noah J.¹^ORCID,Marine Catherine B.¹^ORCID,White Charlie⁴^ORCID,Zhang Zhigang⁴,Barker Christopher A.¹,Kotecha Rupesh⁵^ORCID,McIntosh Alyson⁶^ORCID,Vaynrub Max⁷^ORCID,Bartelstein Meredith K.⁷^ORCID,Mitchell Aaron⁴⁸^ORCID,Guttmann David M.¹,Yerramilli Divya¹^ORCID,Higginson Daniel S.¹^ORCID,Yamada Yoshida J.¹,Kohutek Zachary A.¹⁹,Powell Simon N.¹^ORCID,Tsai Jillian¹¹⁰^ORCID,Yang Jonathan T.¹²

Affiliation:

1. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY

2. Department of Radiation Oncology, University of Washington, Seattle, WA

3. Department of Radiation Oncology, Washington University in St Louis, St Louis, MO

4. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY

5. Department of Radiation Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, FL

6. Department of Radiation Oncology, Lehigh Valley Cancer Institute, Allentown, PAa

7. Department of Surgery, Orthopaedic Service, Memorial Sloan Kettering Cancer Center, New York, NY

8. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY

9. Department of Radiation Oncology, Vanderbilt University, Nashville, TN

10. Department of Radiation Oncology, Princess Margaret Hospital Cancer Centre, Toronto, Ontario, CA

Abstract

In a multicenter RCT (n = 78), radiation to high-risk asymptomatic bone metastases ⬇ skeletal-related events and prolonged OS.

Publisher

American Society of Clinical Oncology (ASCO)

Subject

Cancer Research,Oncology

Link

https://ascopubs.org/doi/pdfdirect/10.1200/JCO.23.00753

Reference21 articles.

1. Metastasis to bone: causes, consequences and therapeutic opportunities

2. Pamidronate prevents skeletal complications and is effective palliative treatment in women with breast carcinoma and osteolytic bone metastases

3. Long-Term Efficacy of Zoledronic Acid for the Prevention of Skeletal Complications in Patients With Metastatic Hormone-Refractory Prostate Cancer

4. Long-term efficacy and safety of zoledronic acid in the treatment of skeletal metastases in patients with nonsmall cell lung carcinoma and other solid tumors

5. Radiation for bone metastases: Reconsidering the optimal timing.

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