Tretinoin Enhances the Effects of Chemotherapy in Juvenile Myelomonocytic Leukemia Using an Ex Vivo Drug Sensitivity Assay

Author:

Stieglitz Elliot1ORCID,Gu Christine J.2,Richardson Michelle2,Kita Ryosuke2ORCID,Santaguida Marianne T.2,Ali Kamran A.2,Strachan Debbie C.2,Dhar Anukriti2ORCID,Yam George2,Anderson Wade2,Anderson Erica2,Hübner Juwita1ORCID,Tasian Sarah K.3ORCID,Loh Mignon L.4ORCID,Lacher Markus D.2ORCID

Affiliation:

1. University of California San Francisco, Benioff Children's Hospital, San Francisco, CA

2. Notable Labs, Foster City, CA

3. Children's Hospital of Philadelphia, Division of Oncology and Center for Childhood Cancer Research and University of Pennsylvania School of Medicine, Philadelphia, PA

4. Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute and Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA

Abstract

Using Notable's ex vivo platform, researchers have identified new preclinical combination therapies in JMML.

Publisher

American Society of Clinical Oncology (ASCO)

Subject

Cancer Research,Oncology

Reference28 articles.

1. Phase II/III trial of a pre-transplant farnesyl transferase inhibitor in juvenile myelomonocytic leukemia: A report from the Children's Oncology Group

2. Current Treatment of Juvenile Myelomonocytic Leukemia

3. Molecular assessment of pretransplant chemotherapy in the treatment of juvenile myelomonocytic leukemia

4. FDA approves azacitidine for newly diagnosed juvenile myelomonocytic leukemia. US Food and Drug Administration. 2022. https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-azacitidine-newly-diagnosed-juvenile-myelomonocytic-leukemia

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