Indium-111–Capromab Pendetide Radioimmunoscintigraphy and Prognosis for Durable Biochemical Response to Salvage Radiation Therapy in Men After Failed Prostatectomy

Author:

Thomas Cherry T.1,Bradshaw Patrick T.1,Pollock Brad H.1,Montie James E.1,Taylor Jeremy M.G.1,Thames Howard D.1,McLaughlin Patrick W.1,DeBiose David A.1,Hussey David H.1,Wahl Richard L.1

Affiliation:

1. From the Division of Radiation Oncology, University of Cincinnati, Barrett Center for Cancer Prevention, Treatment and Research, Cincinnati, OH; Center for Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio, San Antonio; Department of Biomathematics, M.D. Anderson Cancer Center, Houston, TX; Department of Urology, University of Michigan Health Systems; Department of Biostatistics, University of Michigan; Department of Radiation Oncology, University of Michigan Health...

Abstract

Purpose: We evaluated the prognostic significance of indium-111 (111In)–capromab pendetide imaging for patients with prostate cancer who underwent salvage radiotherapy (RT) for recurrent disease after prostatectomy.Patients and Methods: Records were reviewed for all men who underwent111In–capromab pendetide imaging at a single institution from February 1997 through December 1999. We identified 30 eligible men who were radiographically negative for metastatic disease, who had increasing serum prostate-specific antigen (PSA) after primary radical prostatectomy, and who received salvage RT. Clinical interpretations of indium monoclonal antibody (In-mab) scan results were compared with postsalvage RT PSA response.Results: Using an American Society of Therapeutic Radiation and Oncology definition of PSA failure, in men with a positive scan in at least one location (n = 14), the cumulative 2-year PSA control after salvage RT was 0.38 ± 0.13 (± SE) compared with 0.31 ± 0.13 for men with a normal antibody scan in and outside the prostate fossa (n = 15; proportional hazard ratio [PHR] = 1.32; 95% confidence interval [CI], 0.52 to 3.36). For men with a positive antibody scan limited to the prostate fossa (n = 9), PSA control at 2 years was 0.13 ± 0.12 (PHR 1.77; 95% CI, 0.65 to 4.85). The 2-year probability of PSA control after salvage RT for men with positive scan results outside the prostate bed irrespective of In-mab findings in the prostate fossa (n = 5) was 0.60 ± 0.22 (PHR 0.81; 95% CI, 0.17 to 3.78).Conclusion: In contrast to previous reports, for patients with postprostatectomy biochemical relapse who received salvage RT, presalvage RT In-mab scan findings outside the prostate fossa were not predictive of biochemical control after RT.

Publisher

American Society of Clinical Oncology (ASCO)

Subject

Cancer Research,Oncology

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