Phase I and Pharmacokinetic Study of Thalidomide With Carboplatin in Children With Cancer

Abstract

PurposeTumor growth and metastasis is believed to depend on the tumor's ability to induce neovascularization. Recent studies have indicated that thalidomide inhibits angiogenesis. We performed a phase I and pharmacokinetic study of thalidomide with carboplatin in children with refractory solid tumors.Patients and MethodsCarboplatin was administered as a single intravenous dose once every 21 days at a target area under the concentration-time curve of 6 mg/mL·min. Thalidomide was administered daily by mouth. The initial dose level was 100 mg/m2/d with intrapatient dose escalation to a maximum dose of 300 mg/m2/d. The next cohort of patients started at a dose of 300 mg/m2/d, with intrapatient dose escalation to a maximum dose of 500 mg/m2/d. Standard response and adverse event criteria were used. Serial blood samples for thalidomide pharmacokinetics studies were obtained after the first dose.ResultsTwenty-two patients received 56 cycles of therapy. The maximum tolerated thalidomide dose was 400 mg/m2/d. The dose-limiting toxicity was somnolence. There were no objective responses. Thalidomide's apparent clearance was 55 ± 16 mL/min/m2and the terminal half-life was 5.9 ± 2.8 hours. There was no evidence of dose-dependent pharmacokinetics in the narrow range studied.ConclusionThalidomide at a dose of 400 mg/m2/d can be safely administered to children with solid tumors in combination with carboplatin. Somnolence is the major toxicity. In addition, we have characterized the pharmacokinetic behavior of thalidomide in children. This study can serve as the basis for future investigation of thalidomide as an anticancer agent in children.