Affiliation:
1. From the Department of Pathology, Beth Israel Deaconess Medical Center, and Department of Pathology, Harvard Medical School, Boston, MA.
Abstract
ABSTRACT: Vascular endothelial growth factor A (VEGF-A), the founding member of the vascular permeability factor (VPF)/VEGF family of proteins, is an important angiogenic cytokine with critical roles in tumor angiogenesis. This article reviews the literature with regard to VEGF-A’s multiple functions, the mechanisms by which it induces angiogenesis, and its current and projected roles in clinical oncology. VEGF-A is a multifunctional cytokine that is widely expressed by tumor cells and that acts through receptors (VEGFR-1, VEGFR-2, and neuropilin) that are expressed on vascular endothelium and on some other cells. It increases microvascular permeability, induces endothelial cell migration and division, reprograms gene expression, promotes endothelial cell survival, prevents senescence, and induces angiogenesis. Recently, VEGF-A has also been shown to induce lymphangiogenesis. Measurements of circulating levels of VEGF-A may have value in estimating prognosis, and VEGF-A and its receptors are potential targets for therapy. Recognized as the single most important angiogenic cytokine, VEGF-A has a central role in tumor biology and will likely have an important role in future approaches designed to evaluate patient prognosis. It may also become an important target for cancer therapy.
Publisher
American Society of Clinical Oncology (ASCO)
Reference211 articles.
1. Dvorak HF, Orenstein NS, Carvalho AC, et al: Induction of a fibrin-gel investment: An early event in line 10 hepatocarcinoma growth mediated by tumor-secreted products. J Immunol 122: 166,1979-174,
2. Brown LF, Detmar M, Claffey K, et al: Vascular permeability factor/vascular endothelial growth factor: A multifunctional angiogenic cytokine. EXS 79: 233,1997-269,
3. Dvorak HF, Brown LF, Detmar M, et al: Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 146: 1029,1995-1039,
4. Stiver S, Dvorak H: Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF). J Clin Ligand Assay 23: 193,2000-205,
5. Molecular and biological properties of vascular endothelial growth factor
Cited by
1320 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献