Affiliation:
1. From the Leukemia Program, Division of Hematology and Medical Oncology, Oregon Health Sciences University and Veterans Affairs Medical Center, Portland, OR.
Abstract
ABSTRACT: STI571 exemplifies the successful development of a rationally designed, molecularly targeted therapy for the treatment of a specific cancer. This article reviews the identification of Bcr-Abl as a therapeutic target in chronic myelogenous leukemia and the steps in the development of an agent to specifically inactivate this abnormality. Issues related to clinical trials of molecularly targeted agents are discussed, including dose selection, optimizing therapy, and predicting response, as are possible mechanisms of resistance to STI571. Lastly, the potential use of STI571 in other malignancies and the translation of this paradigm to other malignancies are explored.
Publisher
American Society of Clinical Oncology (ASCO)
Cited by
65 articles.
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