Exceptional Response of BRAFV600E-Mutated Acinar Cell CUP to BRAF/MEK Inhibition

Author:

Kerle Irina A.123ORCID,Scheuble Anne-Marie4,Kobitzsch Benjamin4ORCID,Stocker Gertraud4ORCID,Hiller G.G. Ruth5ORCID,Badendick Maja6,William Doreen378910ORCID,Krueger Alexander3789ORCID,Gross Thomas3789,Koegler Anja3789ORCID,Hartig Andreas11,Richter Daniela1212,Aust Daniela E.11ORCID,Schroeck Evelin378910,Heining Christoph123,Glimm Hanno12312ORCID,Hacker Ulrich T.4ORCID

Affiliation:

1. Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany

2. Translational Medical Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany

3. German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany

4. Department of Medicine 2, University Cancer Center Leipzig (UCCL), Leipzig University Medical Center, Cancer Center Central Germany (CCCG), Leipzig, Germany

5. Institute of Pathology, Leipzig University Medical Center, Leipzig, Germany

6. Department of Nuclear Medicine, Leipzig University Medical Center, Leipzig, Germany

7. Core Unit for Molecular Tumor Diagnostics (CMTD), National Center for Tumor Diseases Dresden (NCT/UCC), Dresden, Germany

8. German Cancer Research Center (DKFZ), Heidelberg, Germany

9. Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany

10. Institute for Clinical Genetics, University Hospital Carl Gustav Carus at TU Dresden, Dresden, Germany

11. Institute of Pathology, Carl Gustav Carus University Hospital, Dresden, Germany

12. German Cancer Research Center (DKFZ) Heidelberg, Translational Functional Cancer Genomics, Heidelberg, Germany

Abstract

Complete remission of BRAF V600E-driven ACC CUP by BRAF/MEK inhibition underscores importance of precision oncology.

Publisher

American Society of Clinical Oncology (ASCO)

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