Germline De Novo Mutations as a Cause of Childhood Cancer

Author:

Rashed Wafaa M.1ORCID,Marcotte Erin L.23ORCID,Spector Logan G.23ORCID

Affiliation:

1. Research Department, Children's Cancer Hospital-Egypt 57357 (CCHE-57357), Cairo, Egypt

2. Division of Epidemiology/Clinical, Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN

3. Masonic Cancer Center, University of Minnesota, Minneapolis, MN

Abstract

Germline de novo mutations (DNMs) represent one of the important topics that need extensive attention from epidemiologists, geneticists, and other relevant stakeholders. Advances in next-generation sequencing technologies allowed examination of parent-offspring trios to ascertain the frequency of germline DNMs. Many epidemiological risk factors for childhood cancer are indicative of DNMs as a mechanism. The aim of this review was to give an overview of germline DNMs, their causes in general, and to discuss their relation to childhood cancer risk. In addition, we highlighted existing gaps in knowledge in many topics of germline DNMs in childhood cancer that need exploration and collaborative efforts.

Publisher

American Society of Clinical Oncology (ASCO)

Subject

Cancer Research,Oncology

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