Phase Ib SEASTAR Study: Combining Rucaparib and Sacituzumab Govitecan in Patients With Cancer With or Without Mutations in Homologous Recombination Repair Genes
Author:
Affiliation:
1. The University of Texas MD Anderson Cancer Center, Houston, TX
2. Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN
3. Dana-Farber Cancer Institute, Boston, MA
4. Clovis Oncology Inc, Boulder, CO
Publisher
American Society of Clinical Oncology (ASCO)
Subject
Cancer Research,Oncology
Link
https://ascopubs.org/doi/pdfdirect/10.1200/PO.21.00456
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1. The PARP superfamily
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3. A Synthetic Lethal Therapeutic Approach: Poly(ADP) Ribose Polymerase Inhibitors for the Treatment of Cancers Deficient in DNA Double-Strand Break Repair
4. Rationale for Poly(ADP-ribose) Polymerase (PARP) Inhibitors in Combination Therapy with Camptothecins or Temozolomide Based on PARP Trapping versus Catalytic Inhibition
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