Appetite and Cancer-Associated Anorexia: A Review

Author:

Davis Mellar P.1,Dreicer Robert1,Walsh Declan1,Lagman Ruth1,LeGrand Susan B.1

Affiliation:

1. From the Harry R. Horvitz Center for Palliative Medicine, Department of Hematology/Medical Oncology; the Cleveland Clinic Foundation, and the Cleveland Clinic Taussig Cancer Center Cleveland, OH

Abstract

Appetite is governed by peripheral hormones and central neurotransmitters that act on the arcuate nucleus of the hypothalamus and nucleus tactus solitarius of the brainstem. Cancer anorexia appears to be the result of an imbalance between neuropeptide-Y and pro-opiomelanocortin signals favoring pro-opiomelanocortin. Many of the appetite stimulants redress this imbalance. Most of our understanding of appetite neurophysiology and tumor-associated anorexia is derived from animals and has not been verified in humans. There have been few clinical trials and very little translational research on anorexia despite its prevalence in cancer.

Publisher

American Society of Clinical Oncology (ASCO)

Subject

Cancer Research,Oncology

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