Performance and Operational Feasibility of Epstein-Barr Virus–Based Screening for Detection of Nasopharyngeal Carcinoma: Direct Comparison of Two Alternative Approaches

Author:

Lou Pei-Jen1ORCID,Jacky Lam W.K.2345ORCID,Hsu Wan-Lun67,Pfeiffer Ruth M.8ORCID,Yu Kelly J.8ORCID,Chan Charles M.L.23,Lee Vicky C.T.23,Chen Tseng-Cheng1ORCID,Terng Shyuang-Der9ORCID,Tsou Yung-An10,Leu Yi-Shing11,Liao Li-Jen12,Chang Yen-Liang13,Chien Yin-Chu14,Wang Cheng-Ping1,Lin Ching-Yuan9,Hua Chun-Hung10,Lee Jehn-Chuan11,Yang Tsung-Lin1,Hsiao Chu-Hsing1ORCID,Wu Ming-Shiang1,Tsai Ming-Hsui10,Cheng Hung-Chun9ORCID,Hildesheim Allan8ORCID,Chen Chien-Jen14ORCID,Chan K.C. Allen2345ORCID,Liu Zhiwei8ORCID,Hsu Wan-Lun,Chien Yin-Chu,Chen Chien-Jen,Hildesheim Allan,Pfeiffer Ruth M.,Liu Zhiwei,Yu Kelly J.,Wang Cheng-Ping,Yang Tsung-Lin,Lou Pei-Jen,Chen Chun-Nan,Chen Tseng-Cheng,Lin Chih-Feng,Jian James Jer-Min,Cheng Skye Hongiun,Tsai Yu-Chen,Chung Yih-Lin,Wu Jia-Shing,Liu Ming-Jiung,Huang Kuei-Kang,Tsou Mei-Hua,Chen Hsin-Hsuan,Lin Ching-Yuan,Terng Shyuang-Der,Lin Fang-Yin,Huang Hsin-I,Cheng Hung-Chun,Tsou Yung-An,Hua Chun-Hung,Tsai Ming-Hsui,Leu Yi-Shing,Lee Jehn-Chuan,Liao Li-Jen,Chang Yen-Liang,Hsiao Chu-Hsing,Wu Ming-Shiang,

Affiliation:

1. Department of Otolaryngology, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan

2. Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China

3. Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China

4. State Key Laboratory of Translational Oncology, Sir Y.K. Pao Centre for Cancer, The Chinese University of Hong Kong, Hong Kong SAR, China

5. Centre for Novostics, Hong Kong Science Park, Pak Shek Kok, Hong Kong SAR, China

6. Data Science Center, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan

7. Master Program of Big Data Analysis in Biomedicine, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan

8. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD

9. Division of Head and Neck Surgery, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan

10. Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan

11. Department of Otolaryngology, MacKay Memorial Hospital, Taipei, Taiwan

12. Department of Otolaryngology, Far Eastern Memorial Hospital, New Taipei City, Taiwan

13. Department of Otolaryngology, Cathay General Hospital, Taipei, Taiwan

14. Genomics Research Center, Academia Sinica, Taipei, Taiwan

Abstract

Study directly compared the performance of EBV antibody and EBV DNA testing for NPC detection.

Publisher

American Society of Clinical Oncology (ASCO)

Subject

Cancer Research,Oncology

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