Bone Sarcoma Pathology: Diagnostic Approach for Optimal Therapy

Author:

Rosenberg Andrew E.1

Affiliation:

1. From the Miller School of Medicine, University of Miami, Miami, FL.

Abstract

The pathologic interpretation of malignant bone tumors is one of the more challenging areas in surgical pathology. This is based on the reality that primary bone sarcomas are uncommon, demonstrate significant morphologic heterogeneity, and have a broad spectrum of biology. Accordingly, it is difficult for pathologists to acquire the necessary experience to confidently and accurately diagnose bone sarcomas. The task is further complicated by the fact that it requires the integration of clinical and radiologic information into the diagnostic process. Lastly, molecular aberrations in sarcomas are being newly discovered and their identification is often critical to make specific diagnoses. The pathologist’s role in guiding optimal treatment in biopsy specimens is to make an accurate diagnosis and provide the grade and molecular aberrations when appropriate. The pathology report of resected tumors must confirm this information and assess the surgical resection margins and the percentage of necrosis if the sarcoma has been treated with neoadjuvant systemic therapy.

Publisher

American Society of Clinical Oncology (ASCO)

Subject

General Medicine

Reference8 articles.

1. Unni KK, Inwards CY. Dahlin’s Bone Tumors: General Aspects and Data on 10,165 Cases, 6th Ed. Philadelpha: Lippincott Williams & Wilkins Publishers; 2010.

2. Cancer statistics, 2014

3. Bone cancers

4. Fletcher CDM, Bridge JA, Hogendoorn CW, et al. WHO Classification of Tumours of Soft Tissue and Bone, 4th Ed., Vol. 5. Lyon: International Agency for Research on Cancer; 2013.

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