Lymphocyte surface markers in orbital lymphoid neoplasms.

Author:

Harmon D C,Aisenberg A C,Harris N L,Dallow R L,Linggood R M,Wilkes B M

Abstract

Since the malignant nature of many orbital lymphoid infiltrates is difficult to assess from pathologic examination alone, over the past four years lymphocyte surface marker studies have been added to the evaluation of 23 such cases. Only 10 of the 23 could be confidently classified as malignant lymphoma by histology alone. However, monoclonal surface immunoglobulin was found in 15, supporting the pathologic diagnosis of malignancy in eight and adding seven that could not have been diagnosed otherwise. Clinical evaluation, including a median follow-up of 18 months, revealed manifestations of systemic lymphoma in six of those 15; two had been diagnosed only by surface markers. In contrast, only one of eight cases lacking monoclonal surface immunoglobulin exhibited clinical evidence of malignancy (that case was also indeterminate by histologic criteria). The addition of surface marker analysis permits more accurate diagnosis of orbital lymphoma than is possible from pathologic study alone. This technique can suggest the subtype of lymphoma.

Publisher

American Society of Clinical Oncology (ASCO)

Subject

Cancer Research,Oncology

Cited by 9 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Radiation therapy for primary orbital lymphoma;International Journal of Radiation Oncology*Biology*Physics;1995-02

2. Periocular lymphoproliferative diseases: natural history, prognostic factors, and treatment.;Radiology;1992-10

3. Primary orbital lymphomas;International Journal of Radiation Oncology*Biology*Physics;1988-11

4. Genotypic Monoclonality in Immunophenotypically Polyclonal Orbital Lymphoid Tumors;Ophthalmology;1987-08

5. Orbital Manifestations of Piasmacytic Lymphoproliferations;Ophthalmology;1987-08

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