Multinational, Multicenter Evaluation of Prostate Cancer Tissue in Sub-Saharan Africa: Challenges and Opportunities-Reference-Cited by-同舟云学术

Multinational, Multicenter Evaluation of Prostate Cancer Tissue in Sub-Saharan Africa: Challenges and Opportunities

Published:2024-06 Issue:10 Volume: Page:
ISSN:2687-8941
Container-title:JCO Global Oncology
language:en
Short-container-title:JCO Glob Oncol

Author:

van Wyk Abraham C.¹^ORCID,Lal Priti²^ORCID,Ogunbiyi J. Olufemi³^ORCID,Kyokunda Lynnette⁴,Hobenu Fred⁵,Dial Cherif⁶,Jalloh Mohamed⁶⁷,Gyasi Richard⁸,Oluwole Olabode P.⁹¹⁰,Abrahams Afua D.⁸^ORCID,Botha Adam R.¹¹^ORCID,Mtshali Nompumelelo Zamokuhle¹¹^ORCID,Andrews Caroline¹²^ORCID,Mante Sunny⁵^ORCID,Adusei Ben⁵,Gueye Serigne M.⁶,Mensah James E.⁸^ORCID,Adjei Andrew Anthony⁸,Tettey Yao⁸^ORCID,Adebiyi Akin³,Aisuodionoe-Shadrach Oseremen⁹¹⁰,Eniola Sefiu Bolarinwa⁹¹⁰,Serna Amparo¹³,Yamoah Kosj¹³^ORCID,Chen Wenlong Carl¹⁴¹⁵¹⁶^ORCID,Fernandez Pedro¹⁷^ORCID,Robinson Brian D.¹⁸^ORCID,Mosquera Juan Miguel¹⁸^ORCID,Hsing Ann W.¹⁹²⁰,Agalliu Ilir²¹^ORCID,Rebbeck Timothy R.¹¹^ORCID

Affiliation:

1. Stellenbosch University and National Health Laboratory Service, Tygerberg Hospital, Cape Town, South Africa

2. University of Pennsylvania, Philadelphia, PA

3. University College Hospital/University of Ibadan, Ibadan, Nigeria

4. University of Botswana, Gaborone, Botswana

5. 37 Military Hospital, Accra, Ghana

6. Hôpital Général Idrissa Pouye, Dakar, Sénégal

7. Ecole Doctorale Universite Iba Der Thiam, Thiés, Sénégal

8. Korle-Bu Teaching Hospital, Accra, Ghana

9. University of Abuja, Abuja, Nigeria

10. Cancer Science Centre, Abuja and University of Abuja Teaching Hospital, Abuja, Nigeria

11. Department of Anatomical Pathology, Faculty of Health Sciences, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg, South Africa

12. Dana-Farber Cancer Institute, Boston, MA

13. Moffitt Cancer Center & Research Institute, Tampa, FL

14. National Cancer Registry, National Institute for Communicable Diseases a Division of the National Health Laboratory Service, Johannesburg, South Africa

15. Strengthening Oncology Services Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

16. Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

17. Division of Urology, Department of Surgical Sciences, Stellenbosch University, Cape Town, South Africa

18. Weill Cornell Medical Center, New York, NY

19. Stanford Cancer Institute, Stanford School of Medicine, Palo Alto, CA

20. Stanford Prevention Research Center, Stanford School of Medicine, Palo Alto, CA

21. Albert Einstein College of Medicine, New York, NY

Abstract

PURPOSE Prostate cancer disproportionately affects men of African descent, yet their representation in tissue-based studies is limited. This multinational, multicenter pilot study aims to establish the groundwork for collaborative research on prostate cancer in sub-Saharan Africa. METHODS The Men of African Descent and Carcinoma of the Prostate network formed a pathologist working group representing eight institutions in five African countries. Formalin-fixed paraffin-embedded prostate tissue specimens were collected from Senegal, Nigeria, and Ghana. Histology slides were produced and digitally scanned. A central genitourinary pathologist (P.L.) and eight African general pathologists reviewed anonymized digital whole-slide images for International Society of Urological Pathology grade groups and other pathologic parameters. Discrepancies were re-evaluated, and consensus grading was assigned. A virtual training seminar on prostate cancer grading was followed by a second assessment on a subcohort of the same tissue set. RESULTS Of 134 tissue blocks, 133 had evaluable tissue; 13 lacked cancer evidence, and four were of insufficient quality. Post-training, interobserver agreement for grade groups improved to 56%, with a median Cohen's quadratic weighted kappa of 0.83 (mean, 0.74), compared with an initial 46% agreement and a quadratic weighted kappa of 0.77. Interobserver agreement between African pathologist groups was 40%, with a quadratic weighted kappa of 0.66 (95% CI, 0.51 to 0.76). African pathologists tended to overgrade (36%) more frequently than undergrade (18%) compared with the reference genitourinary pathologist. Interobserver variability tended to worsen with a decrease in tissue quality. CONCLUSION Tissue-based studies on prostate cancer in men of African descent are essential for a better understanding of this common disease. Standardized tissue handling protocols are crucial to ensure good tissue quality and data. The use of digital slide imaging can enhance collaboration among pathologists in multinational, multicenter studies.

Publisher

American Society of Clinical Oncology (ASCO)

Link

https://ascopubs.org/doi/pdfdirect/10.1200/GO.23.00403

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