1. From the London Regional Cancer Centre, London, Ontario, Canada; Leicester Royal Infirmary, Leicester, University College London Hospitals National Health Service Trust, London, Royal Victoria Infirmary, Newcastle upon Tyne, Royal Orthopaedic Hospital National Health Service Trust, Birmingham, Royal National Orthopedic Hospital, London, and Medical Research Council Cancer Trials Office, Cambridge, United Kingdom; Leiden University Medical Centre, Leiden, the Netherlands; and European Organization for...