Phase I study of AZD3759, a CNS penetrable EGFR inhibitor, for the treatment of non-small-cell lung cancer (NSCLC) with brain metastasis (BM) and leptomeningeal metastasis (LM).

Author:

Ahn Myung-Ju1,Kim Dong-Wan2,Kim Tae Min3,Lin Chia-Chi4,Ratnayake Jayantha5,Carlie David J6,Yin Xiaolu7,Yang Zhenfan8,Jiang Haiyi9,Yang James Chih-Hsin10

Affiliation:

1. Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea;

2. Seoul National University Hospital, Seoul, South Korea;

3. Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, The Republic of;

4. National Taiwan University Hospital, Taipei, Taiwan;

5. Global Medicine Development, AstraZeneca, Alderly Park, United Kingdom;

6. Early Clinical Development, AstraZeneca, Alderly Park, United Kingdom;

7. Innovation Center China, Innovative Medicines & Early Development, Shanghai, China;

8. Innovation Center China, Innovative Medicines & Early Development, AstraZeneca, Shanghai, China;

9. AstraZeneca China, Shanghai, China;

10. National Taiwan University, Taipei, Taiwan;

Publisher

American Society of Clinical Oncology (ASCO)

Subject

Cancer Research,Oncology

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