Genomic analysis and 3-y efficacy and safety update of COMBI-d: A phase 3 study of dabrafenib (D) + trametinib (T) vs D monotherapy in patients (pts) with unresectable or metastatic BRAF V600E/K-mutant cutaneous melanoma.

Author:

Flaherty Keith1,Davies Michael A.2,Grob Jean Jacques3,Long Georgina V.4,Nathan Paul D.5,Ribas Antoni6,Robert Caroline7,Schadendorf Dirk8,Frederick Dennie T9,Hammond Marc R9,Jane-Valbuena Judit10,Mu Xinmeng Jasmine10,Squires Matthew11,Jaeger Savina A.12,Lane Stephen R.13,Mookerjee Bijoyesh13,Garraway Levi A.10

Affiliation:

1. Dana-Farber Cancer Institute/Harvard Medical School and Massachusetts General Hospital, Boston, MA;

2. The University of Texas MD Anderson Cancer Center, Houston, TX;

3. Aix-Marseille University, Marseille, France;

4. Melanoma Institute of Australia and The University of Sydney, Sydney, Australia;

5. Mount Vernon Cancer Centre, Northwood, United Kingdom;

6. UCLA and the Jonsson Comprehensive Cancer Center, Los Angeles, CA;

7. Gustave Roussy Comprehensive Cancer Center, Villejuif, France;

8. University Hospital of Essen, Essen, Germany;

9. Massachusetts General Hospital, Boston, MA;

10. Dana-Farber Cancer Institute/Harvard Medical School and Broad Institute, Cambridge, MA;

11. Novartis Pharma AG, Basel, Switzerland;

12. Novartis Institutes for BioMedical Research, Inc, Cambridge, MA;

13. Novartis Pharmaceuticals Corporation, East Hanover, NJ;

Publisher

American Society of Clinical Oncology (ASCO)

Subject

Cancer Research,Oncology

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