Overall survival in COMBI-d, a randomized, double-blinded, phase III study comparing the combination of dabrafenib and trametinib with dabrafenib and placebo as first-line therapy in patients (pts) with unresectable or metastatic BRAF V600E/Kmutation-positive cutaneous melanoma.

Author:

Long Georgina V.1,Stroyakovskiy Daniil2,Gogas Helen3,Levchenko Evgeny4,De Braud Filippo G.5,Larkin James M. G.6,Garbe Claus7,Jouary Thomas8,Hauschild Axel9,Grob Jean Jacques10,Chiarion-Sileni Vanna11,Lebbe Celeste12,Mandalà Mario13,Millward Michael14,DeMarini Douglas James15,Irani Jhangir G15,Jin Fan15,Swann R. Suzanne15,Mookerjee Bijoyesh15,Flaherty Keith16

Affiliation:

1. Melanoma Institute Australia and The University of Sydney, North Sydney, Australia

2. Moscow City Oncology Hospital #62, Chemotherapy Department, Moscow, Russia

3. 1st Department of Medicine, Medical School, University of Athens, Athens, Greece

4. Petrov Research Institute of Oncology, Saint Petersburg, Russia

5. Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

6. The Royal Marsden NHS Foundation Trust, London, United Kingdom

7. University of Tübingen, Tübingen, Germany

8. Hôpital François Mitterrand, Pau, France

9. University of Kiel, Kiel, Germany

10. Aix-Marseille University, Hopital de la Timone, Marseille, France

11. Veneto Oncology Institute, Padova, Italy

12. Dermatology Department, Hôpital Saint-Louis, Assistance-Publique-Hôpitaux de Paris, Paris, France

13. Papa Giovanni XXIII Hospital, Bergamo, Italy

14. Sir Charles Gairdner Hospital, Perth, Australia

15. GlaxoSmithKline, Collegeville, PA

16. Massachusetts General Hospital and Dana-Farber Cancer Institute, Boston, MA

Publisher

American Society of Clinical Oncology (ASCO)

Subject

Cancer Research,Oncology

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