A phase 1 study of LOXO-292, a potent and highly selective RET inhibitor, in patients with RET-altered cancers.

Author:

Drilon Alexander E.1,Subbiah Vivek2,Oxnard Geoffrey R.3,Bauer Todd Michael4,Velcheti Vamsidhar5,Lakhani Nehal J.6,Besse Benjamin7,Park Keunchil8,Patel Jyoti D.9,Cabanillas Maria E.2,Johnson Melissa Lynne10,Reckamp Karen L.11,Boni Valentina12,Loong Herbert H. F.13,Schlumberger Martin14,Solomon Ben15,Cruickshank Scott16,Rothenberg Stephen M.17,Shah Manisha H.18,Wirth Lori J.19

Affiliation:

1. Memorial Sloan Kettering Cancer Center, New York, NY;

2. The University of Texas MD Anderson Cancer Center, Houston, TX;

3. Dana-Farber Cancer Institute, Boston, MA;

4. Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN;

5. Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;

6. START Midwest, Grand Rapids, MI;

7. Gustave Roussy, Villejuif, France;

8. Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;

9. University of Chicago, Chicago, IL;

10. Sarah Cannon Research Institute, Nashville, TN;

11. City of Hope Comprehensive Cancer Center, Duarte, CA;

12. START Madrid CIOCC Hospital Universitario Sanchinarro, Madrid, Spain;

13. The Chinese University of Hong Kong, Shatin, Hong Kong;

14. Institut Gustave Roussy, Villejuif, France;

15. Peter MacCallum Cancer Centre, East Melbourne, Australia;

16. Loxo Oncology, South San Francisco, CA;

17. Loxo Oncology, Stamford, CT;

18. The Ohio State University Comprehensive Cancer Center, Columbus, OH;

19. Massachusetts General Hospital Cancer Center, Boston, MA;

Publisher

American Society of Clinical Oncology (ASCO)

Subject

Cancer Research,Oncology

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