Induction of Cutaneous Squamous Cell Carcinomas by RAF Inhibitors: Cause for Concern?
Author:
Affiliation:
1. Memorial Sloan-Kettering Cancer Center, New York, NY
2. New York University, New York, NY
Publisher
American Society of Clinical Oncology (ASCO)
Subject
Cancer Research,Oncology
Link
http://ascopubs.org/doi/pdfdirect/10.1200/JCO.2011.38.2895
Reference13 articles.
1. Mutations of the BRAF gene in human cancer
2. Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
3. The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner
4. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
5. Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF
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