Metathramycin, a new bioactive aureolic acid discovered by heterologous expression of a metagenome derived biosynthetic pathway-Reference-Cited by-同舟云学术

Metathramycin, a new bioactive aureolic acid discovered by heterologous expression of a metagenome derived biosynthetic pathway

Published:2021 Issue:2 Volume:2 Page:556-567
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Stevenson Luke J.¹²³⁴⁵^ORCID,Bracegirdle Joe⁵⁴⁶¹²^ORCID,Liu Liwei¹²³⁴,Sharrock Abigail V.¹²³⁴⁵^ORCID,Ackerley David F.¹²³⁴⁵^ORCID,Keyzers Robert A.⁵⁴⁶¹²^ORCID,Owen Jeremy G.¹²³⁴⁵^ORCID

Affiliation:

1. School of Biological Sciences

2. Victoria University of Wellington

3. Wellington

4. New Zealand

5. Maurice Wilkins Centre for Molecular Biodiscovery

6. Centre for Biodiscovery

Abstract

Heterologous expression of an aromatic polyketide biosynthetic gene cluster recovered from a New Zealand soil metagenome library resulted in the discovery of new bioactive aureolic acids.

Funder

Ministry of Business, Innovation and Employment

Health Research Council of New Zealand

Royal Society of New Zealand

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CB/D0CB00228C

Reference50 articles.

1. The aureolic acid family of antitumor compounds: structure, mode of action, biosynthesis, and novel derivatives

2. Mithramycin SK, A Novel Antitumor Drug with Improved Therapeutic Index, Mithramycin SA, and Demycarosyl-mithramycin SK: Three New Products Generated in the Mithramycin Producer Streptomyces argillaceus through Combinatorial Biosynthesis

3. The Mithramycin Gene Cluster of Streptomyces argillaceus Contains a Positive Regulatory Gene and Two Repeated DNA Sequences That Are Located at Both Ends of the Cluster

4. Exploring Novel Opportunities for Aureolic Acids as Anticancer Drugs

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