Intermediary conformations linked to the directionality of the aminoacylation pathway of nonribosomal peptide synthetases-Reference-Cited by-同舟云学术

Intermediary conformations linked to the directionality of the aminoacylation pathway of nonribosomal peptide synthetases

Published:2021 Issue:3 Volume:2 Page:843-854
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Mayerthaler Florian¹²³⁴⁵^ORCID,Feldberg Anna-Lena¹²³⁴⁵^ORCID,Alfermann Jonas¹²³⁴⁵,Sun Xun⁶⁷⁸⁹^ORCID,Steinchen Wieland¹⁰¹¹⁵^ORCID,Yang Haw⁶⁷⁸⁹^ORCID,Mootz Henning D.¹²³⁴⁵^ORCID

Affiliation:

1. Institute of Biochemistry

2. Department of Chemistry and Pharmacy

3. University of Muenster

4. Münster

5. Germany

6. Department of Chemistry

7. Princeton University

8. Princeton

9. USA

10. SYNMIKRO Research Center & Faculty of Chemistry

11. Philipps-University Marburg

Abstract

In-solution analysis of conformational changes of NRPS adenylation and peptidyl-carrier protein domains under catalytic conditions reveals a new intermediary conformation.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CB/D0CB00220H

Reference52 articles.

1. Nonribosomal Peptide Synthesis-Principles and Prospects

2. Modular Peptide Synthetases Involved in Nonribosomal Peptide Synthesis

3. Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology