Molecular investigation of the dual inhibition mechanism for targeted P53 regulator MDM2/MDMX inhibitors-Reference-Cited by-同舟云学术

Molecular investigation of the dual inhibition mechanism for targeted P53 regulator MDM2/MDMX inhibitors

Published:2022 Issue:27 Volume:24 Page:16799-16815
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Zhao Xiaoyu¹,Xiong Danyang¹,Luo Song¹,Duan Lili¹^ORCID

Affiliation:

1. School of Physics and Electronics, Shandong Normal University, Jinan, 250014, China

Abstract

Residues I61/60, M62/61, Y67/66, V93/92, and L54/M53 provide a vital condition for dual inhibition of MDM2/MDMX by inhibitors. Stronger attraction of H96/I99 in MDM2 to inhibitors leads to the ineffectiveness of targeted MDM2 inhibitors against MDMX.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CP/D2CP01780F

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