Indolo[2,3-e]benzazocines and indolo[2,3-f]benzazonines and their copper(ii) complexes as microtubule destabilizing agents

Author:

Wittmann Christopher1,Dömötör Orsolya2ORCID,Kuznetcova Irina1ORCID,Spengler Gabriella23,Reynisson Jóhannes4ORCID,Holder Lauren4,Miller Gavin J.4ORCID,Enyedy Eva A.2ORCID,Bai Ruoli5,Hamel Ernest5,Arion Vladimir B.1ORCID

Affiliation:

1. Institute of Inorganic Chemistry, University of Vienna, Währinger Strasse 42, A-1090 Vienna, Austria

2. MTA-SZTE Lendület Functional Metal Complexes Research Group, Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7, H-6720 Szeged, Hungary

3. Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis u. 6, H-6725 Szeged, Hungary

4. Schools of Chemical and Physical Sciences and Pharmacy and Bioengineering, Keele University, Staffordshire, ST5 5BG, UK

5. Molecular Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Diagnosis and Treatment, National Cancer Institute, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, Maryland 21702, USA

Abstract

The tridentate ligand HL1 and its complex 1 showed good antiproliferative activity by inhibition of tubulin assembly.

Funder

Austrian Science Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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