Highly efficient gene release in spatiotemporal precision approached by light and pH dual responsive copolymers-Reference-Cited by-同舟云学术

Highly efficient gene release in spatiotemporal precision approached by light and pH dual responsive copolymers

Published:2019 Issue:1 Volume:10 Page:284-292
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Lu Hung-Hsun¹²³⁴⁵,Huang Cheng-Hung¹²³⁴⁵,Shiue Ting-Yun⁶²³⁴⁵,Wang Fu-Sheng¹²³⁴⁵,Chang Ko-Kai¹²³⁴⁵,Chen Yunching⁶²³⁴⁵,Peng Chi-How¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Frontier Research Center on Fundamental and Applied Sciences of Matters

3. National Tsing Hua University

4. Hsinchu 30013

5. Taiwan

6. Institute of Biomedical Engineering

Abstract

Triblock copolymer, PEG-b-PDMAEMA-b-PPy, has been shown as an ideal carrier with remarkable siRNA condensation, high stability, efficient gene release, and negligible cytotoxicity for gene delivery.

Funder

Ministry of Science and Technology, Taiwan

National Health Research Institutes

Ministry of Education

National Tsing Hua University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C8SC01494A

Reference54 articles.

1. Delivery materials for siRNA therapeutics

2. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

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4. Polymers for siRNA Delivery: Inspired by Viruses to be Targeted, Dynamic, and Precise

5. Progress towards in Vivo Use of siRNAs

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