Cyclometalated Ru(<scp>ii</scp>)–NHC complexes with phenanthroline ligands induce apoptosis mediated by mitochondria and endoplasmic reticulum stress in cancer cells-Reference-Cited by-同舟云学术

Cyclometalated Ru(ii)–NHC complexes with phenanthroline ligands induce apoptosis mediated by mitochondria and endoplasmic reticulum stress in cancer cells

Published:2023 Issue:6 Volume:52 Page:1671-1679
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Chen Chao¹²^ORCID,Lv He²,Xu Hao¹,Zhu Dancheng¹,Shen Chao¹^ORCID

Affiliation:

1. Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China

2. College of Life Sciences, Huzhou University, Huzhou, 313000, PR China

Abstract

Four cyclometalated Ru(ii) complexes with pyridine-functionalized NHC ligands were synthesized and characterized. The anticancer study showed that Ru3 and Ru4 caused the dual action modes and finally induced apoptosis of HeLa cells.

Funder

Zhejiang Shuren University

Natural Science Foundation of Zhejiang Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/DT/D2DT03405K

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