Oxygen control: the often overlooked but essential piece to create betterin vitrosystems

Author:

Palacio-Castañeda Valentina1ORCID,Velthuijs Niels1ORCID,Le Gac Séverine2ORCID,Verdurmen Wouter P. R.1ORCID

Affiliation:

1. Department of Biochemistry, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands

2. Applied Microfluidics for BioEngineering Research, MESA+ Institute for Nanotechnology & TechMed Centre, Organ-on-a-chip Centre, University of Twente, Postbus 217, 7500 AE Enschede, The Netherlands

Abstract

Variations in oxygen levels play key roles in numerous physiological and pathological processes, but are often not properly controlled inin vitromodels, introducing a significant bias in experimental outcomes.

Funder

Radboud Universitair Medisch Centrum

University of Twente

Health~Holland

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

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