Increase in the apparent intercalation ability of a platinum complex via multivalency by installation into the sidechain of a graft copolymer and observation of structural changes in the intercalated DNA
Author:
Affiliation:
1. Department of Applied Chemistry
2. Faculty of Science Division I
3. Tokyo University of Science
4. Tokyo 162-8601
5. Japan
6. Graduate School of Science
Abstract
Pt complexes increase their apparent binding constant by grafting on sidechains of polymer segments via multivalent effect.
Funder
Ministry of Education, Culture, Sports, Science and Technology
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA03485D
Reference23 articles.
1. Stereochemical Requirements for Intercalation of Platinum Complexes into Double-Stranded DNA's
2. The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs
3. Metal complex interactions with DNA
4. DNA binding and cleavage properties of a newly synthesised Ru(II)-polypyridyl complex
5. Circular dichroism and conformational polymorphism of DNA
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