A binary matrix for the rapid detection and characterization of small-molecule cardiovascular drugs by MALDI-MS and MS/MS-Reference-Cited by-同舟云学术

A binary matrix for the rapid detection and characterization of small-molecule cardiovascular drugs by MALDI-MS and MS/MS

Published:2018 Issue:6 Volume:10 Page:572-578
ISSN:1759-9660
Container-title:Analytical Methods
language:en
Short-container-title:Anal. Methods

Author:

Dong Jinlan¹²³⁴⁵,Ning Wenjing¹²³⁴⁵,Mans Daniel J.¹²³⁴⁵,Mans Jamie D.¹²³⁴⁵^ORCID

Affiliation:

1. Division of Pharmaceutical Analysis

2. Center for Drug Evaluation and Research

3. Food and Drug Administration

4. St. Louis

5. USA

Abstract

A mixture of α-cyano-4-hydroxycinnamic acid and 1,5-diaminonaphthalene was discovered as a novel binary matrix for the qualitative analysis of 14 small-molecule (∼250–550 Da) cardiovascular drugs by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) and MS/MS in either positive or negative ion mode.

Funder

U.S. Food and Drug Administration

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/AY/C7AY02583A

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