Choosing proper normalization is essential for discovery of sparse glycan biomarkers-Reference-Cited by-同舟云学术

Choosing proper normalization is essential for discovery of sparse glycan biomarkers

Published:2020 Issue:3 Volume:16 Page:231-242
ISSN:2515-4184
Container-title:Molecular Omics
language:en
Short-container-title:Mol. Omics

Author:

Uh Hae-Won¹²³⁴^ORCID,Klarić Lucija⁵⁶⁷⁸⁹^ORCID,Ugrina Ivo⁵⁶⁷¹⁰¹¹,Lauc Gordan⁵⁶⁷¹²¹³,Smilde Age K.¹⁴¹⁵¹⁶¹⁷¹⁸,Houwing-Duistermaat Jeanine J.¹²³⁴¹⁹

Affiliation:

1. Department of Biostatistics and Research Support

2. University Medical Center Utrecht

3. Utrecht

4. Netherlands

5. Genos Glycoscience Research Laboratory

6. Zagreb

7. Croatia

8. MRC Human Genetics Unit

9. MRC Institute of Genetics and Molecular Medicine

10. University of Split

11. Faculty of Science

12. Faculty of Pharmacy and Biochemistry

13. University of Zagreb

14. Biosystems Data Analysis

15. Swammerdam Institute for Life Sciences

16. University of Amsterdam

17. Amsterdam

18. The Netherlands

19. Department of Statistics

Abstract

In this work we assess the effect of different normalization methods on variable selection in an emerging field of glycomics.

Funder

Seventh Framework Programme

Horizon 2020 Framework Programme

Royal Society

Arthritis Research UK

Research Councils UK

Sixth Framework Programme

Publisher

Royal Society of Chemistry (RSC)

Subject

Genetics,Molecular Biology,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/MO/C9MO00174C

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2. Glycans Are a Novel Biomarker of Chronological and Biological Ages

3. Plasma protein N-glycan profiles are associated with calendar age, familial longevity and health

4. N-glycan profiles as tools in diagnosis of hepatocellular carcinoma and prediction of healthy human ageing

5. Proposed minimum reporting standards for data analysis in metabolomics

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