A dual-response drug delivery system with X-ray and ROS to boost the anti-tumor efficiency of TPZ <i>via</i> enhancement of tumor hypoxia levels-Reference-Cited by-同舟云学术

A dual-response drug delivery system with X-ray and ROS to boost the anti-tumor efficiency of TPZ via enhancement of tumor hypoxia levels

Published:2023 Issue:1 Volume:15 Page:237-247
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Han Panli¹²,Zhang Lianxue²,Fu Yaqi²,Fu Youyu²,Huang Jianxiang²,He Jinlin³^ORCID,Ni Peihong³^ORCID,Khan Taimoor²,Jiao Yang¹,Yang Zaixing¹²^ORCID,Zhou Ruhong²⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou 215123, China

2. Institute of Quantitative Biology, Shanghai Institute for Advanced Study, College of Life Sciences, Zhejiang University, Hangzhou 310027, China

3. College of Chemistry, Chemical Engineering and Materials Science, State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, Soochow University, Suzhou 215123, China

4. Cancer Center, Zhejiang University, Hangzhou 310058, China

5. Department of Chemistry, Columbia University, New York, New York 10027, USA

Abstract

The selective anti-tumor activity and less toxic nature of hypoxia-activated prodrugs including tirapazamine (TPZ) are harbored by hypoxia levels in tumors, the inadequacy of which leads to failure in clinical trials.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Natural Science Foundation of Zhejiang Province

W. M. Keck Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NR/D2NR04021B